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Related Concept Videos

Anxiolytic Drugs: Benzodiazepines and Buspirone01:29

Anxiolytic Drugs: Benzodiazepines and Buspirone

Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Anxiolytic Drugs: Overview01:26

Anxiolytic Drugs: Overview

Anxiolytic drugs are vital in managing anxiety disorders by effectively alleviating symptoms such as excessive fear, tachycardia, and tremors. There are several classes of anxiolytic medications, each with unique mechanisms of action and potential side effects.
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic circuitry.
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
Anxiety: Overview01:18

Anxiety: Overview

Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Generalized Anxiety Disorder01:30

Generalized Anxiety Disorder

Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...

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Related Experiment Video

Updated: May 29, 2026

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat
11:18

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Published on: September 12, 2014

Prochlorperazine in anxiety.

P Nigam1, C K Rastogi, K K Kapoor

  • 1Reader in Medicine, Baba Raghav Das Medical College and Nehru Chikitsalaya, GORAKHPUR 273 013, U. P.

Indian Journal of Psychiatry
|September 20, 2011
PubMed
Summary
This summary is machine-generated.

Prochlorperazine significantly reduced anxiety symptoms more effectively than other drugs in a 4-week trial. This anxiolytic drug demonstrated faster, optimal improvement with fewer side effects, enhancing anxiety management.

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Reducing State Anxiety Using Working Memory Maintenance
08:17

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Last Updated: May 29, 2026

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat
11:18

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Published on: September 12, 2014

Reducing State Anxiety Using Working Memory Maintenance
08:17

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Anxiety disorders are prevalent, necessitating effective treatment options.
  • Established anxiolytics like Chlordiazepoxide have known efficacy and side effect profiles.

Purpose of the Study:

  • To compare the efficacy and safety of Prochlorperazine against other anxiolytic drugs.
  • To evaluate the speed and degree of anxiety symptom reduction.

Main Methods:

  • A randomized clinical trial involving seventy patients with primary anxiety state.
  • Utilized Hamilton's anxiety scale for quantitative assessment.
  • Patients were assigned to Prochlorperazine (Group I) or other anxiolytics (Group II) for 4 weeks.

Main Results:

  • Both groups showed significant anxiety score reduction, with Group I exhibiting a greater decrease (P < 0.001).
  • Group I achieved significantly more and faster clinical improvement (85% vs. 70%, P < 0.02).
  • Prochlorperazine (Group I) demonstrated the fewest side effects.

Conclusions:

  • Prochlorperazine exhibits significant anxiolytic effects without impairing mental function.
  • Prochlorperazine is a safe and effective option for managing anxiety at the tested dosage.
  • The study supports Prochlorperazine's utility in clinical anxiety management.