Tardive dyskinesia: a potential new neurochemical animal model

Conventional neurochemical animal models of tardive dyskinesia are based upon the production of dopamine postsynaptic receptor supersensitivity by the chronic administration of neuroleptics. This study demonstrates that the same result is obtained by injecting Sprague-Dawley rats with a single ('high') dose of ipomorphine. It is hence suggested that apomorphine-induced time-dependant potentiation of dopaminepostsynaptic receptor response may be a more convenient neurochemical animal model of tardive dyskinesia; related theoretical and practical issues are discussed briefly, as also he methodological differences between the present study and an earlier report.