Related Experiment Video
Updated: May 29, 2026

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens
Published on: September 20, 2024
Immunoglobulins and viral antibodies in depressive patients
S C Tiwari1, N Lal, J K Trivedi
1Lecturer, Department of Psychiatry, K.G.'s Medical College, Lucknow.
Abstract:
Patterns of serum and C.S.F. IgG, IgA and IgM, and haemagglutination inhibiting (HI) antibodies and complement fixing (CF) antibodies against rubella and cytomegaloviruses respectively and total CSF protein were investigated in 30 depressives, 20 each in neurological and surgical patients. Significant changes in total CSF protein and immunoglobulins in depressives and neurological patients in comparison to surgical subjects indicate an etiological similarity between the two groups. Failure to detect antibodies in C.S.F. of these subjects and statistically insignificant seropositivity refute the claim of viral hypothesis for depression but similar alterations in these body proteins in depressives and neurological patients raise other aetiological possibilities.
Related Concept Videos
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depressive Disorders: MDD and Dysthymia
Humoral Immune Responses
Inhibitors of Viral Protein Synthesis
Depression: Overview
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

