Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The relationship between atopy and non-specific bronchial responsiveness.

D N Grainger1, S C Stenton, A J Avery

  • 1Chest Unit, Newcastle General Hospital, University of Newcastle upon Tyne, U.K.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|March 1, 1990
PubMed
Summary

Atopy is associated with non-specific bronchial responsiveness (NSBR), but this link is weak and depends on how atopy is defined. Atopy should not be used as a marker for NSBR in asthma research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Popcorn worker's lung" in Britain in a man making potato crisp flavouring.

BMJ case reports·2025
Same author

Disease burden, comorbidities and antecedents of chronic cough phenotypes in Australian adults.

Pulmonology·2023
Same author

Preclinical interstitial lung disease in relatives of familial pulmonary fibrosis patients.

Pulmonology·2022
Same author

The PEARL score predicts 90-day readmission or death after hospitalisation for acute exacerbation of COPD.

Thorax·2017
Same author

Mould-sensitized adults have lower Th2 cytokines and a higher prevalence of asthma than those sensitized to other aeroallergens.

Allergy·2016
Same author

Validation of the DECAF score to predict hospital mortality in acute exacerbations of COPD.

Thorax·2016

Area of Science:

  • Allergy and Immunology
  • Pulmonary Medicine
  • Respiratory Health

Background:

  • Atopy is a known risk factor for asthma development, particularly in children and occupational settings.
  • The relationship between atopy and non-specific bronchial responsiveness (NSBR) in asthma is not fully understood.
  • Atopy may influence asthma independently or through its association with NSBR.

Purpose of the Study:

  • To investigate the association between atopy and NSBR in siblings of individuals with atopic asthma.
  • To determine if atopy is a reliable predictor of NSBR.
  • To examine how different definitions of atopy affect its association with NSBR.

Main Methods:

  • Evaluated 59 siblings of probands with atopic asthma.
  • Assessed atopy using skin prick tests and serum total IgE levels.

Related Experiment Videos

  • Measured NSBR via methacholine challenge (PD20FEV1).

    • Main Results:

    • 58% of subjects were atopic and 47% exhibited NSBR.
    • A statistically significant association was found between atopy and NSBR when specific criteria were used (P < 0.05).
    • The association was not consistently observed across all definitions of atopy, and NSBR was more strongly influenced by baseline FEV1 than atopic status.

    Conclusions:

    • Atopy is weakly associated with NSBR, and this relationship is sensitive to the diagnostic criteria for atopy.
    • Atopy is not a strong or reliable marker for predicting NSBR.
    • Further research is needed to clarify the complex interplay between atopy, NSBR, and asthma development.