Related Experiment Video
Updated: May 29, 2026
07:31
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
Published on: December 2, 2016
[Hypertrophic cardiomyopathy with left ventricular aneurysm].
Ewelina Becherka1, Jarosław D Kasprzak, Jerzy Górny
1II Katedra Kardiologii, Uniwersytet Medyczny w Łodzi, Łódź. ebecherka@wp.pl
Kardiologia Polska
|September 20, 2011
Summary
This case study highlights a 68-year-old woman with hypertrophic cardiomyopathy who developed dyspnea post-acute coronary syndrome. Echocardiography revealed left ventricular aneurysm and intraventricular gradients, indicating complex cardiac dynamics.
Area of Science:
- Cardiology
- Cardiac Imaging
- Cardiovascular Disease
Background:
- Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease.
- Acute coronary syndrome (ACS) can precipitate or exacerbate cardiac complications.
- Left ventricular (LV) dysfunction requires careful diagnostic evaluation.
Observation:
- A 68-year-old woman with known HCM presented with progressive dyspnea following ACS.
- Echocardiography demonstrated hypertrophic hypertrophy and an apical LV aneurysm.
- Doppler-echocardiography identified midventricular and subaortic intra-LV gradients.
Findings:
- The patient exhibited significant intraventricular pressure gradients.
- Systolic anterior motion of the anterior mitral leaflet was observed.
- The combination of HCM, LV aneurysm, and intraventricular gradients presents a complex clinical scenario.
Implications:
- This case underscores the importance of comprehensive echocardiographic assessment in HCM patients with worsening symptoms after ACS.
- Understanding intraventricular gradients and LV aneurysm is crucial for managing dyspnea and preventing adverse outcomes.
- Further research may explore the specific mechanisms linking ACS, LV aneurysm formation, and gradient development in HCM.
Related Concept Videos
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
01:20Mitral Regurgitation I: Introduction
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
01:30Cardiomyopathy II: Dilated Cardiomyopathy
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
01:29Heart Failure II: Pathophysiology
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
01:30Aneurysm I: Introduction
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
01:22Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...