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Updated: May 29, 2026

Cell Population Analyses During Skin Carcinogenesis

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Concurrent basal cell and squamous cell carcinomas associated with hydroxyurea therapy.

Jelena Radić¹, Tanja Batinac, Ita Hadžisejdić

¹Department of Pathology, School of Medicine, University of Rijeka, Croatia.

Acta Dermatovenerologica Croatica : ADC

|September 22, 2011

Summary

Hydroxyurea (HU) therapy may increase skin cancer risk. This case study suggests a link between HU, DNA repair, and concurrent basal cell and squamous cell carcinomas, even without HPV.

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Published on: August 9, 2024

Area of Science:

Dermatology
Oncology
Pharmacology

Background:

Long-term hydroxyurea (HU) therapy is used for myeloproliferative neoplasms like polycythemia vera.
Cutaneous malignancies are a known side effect, but concurrent dual primary skin cancers are rare.
Ultraviolet (UV) exposure is a primary risk factor for skin cancer.

Observation:

A 76-year-old woman on long-term HU developed two distinct primary skin cancers on the same hand: basal cell carcinoma and sarcomatoid squamous cell carcinoma.
Histopathology confirmed distinct tumor types with specific protein expressions (bcl-2, vimentin, EMA, CK5/6, p53).
Low-risk human papillomavirus (HPV) was detected in surrounding skin but not within the tumors.

Findings:

The concurrence of two different skin carcinomas, in the absence of HPV, suggests a potential role for mutagenic HU therapy.
HU may influence DNA synthesis and repair mechanisms, exacerbating UV-induced carcinogenesis.
p53 overexpression was noted in both tumor types, indicating potential DNA damage response alterations.

Implications:

Patients on HU therapy with cutaneous side effects warrant close dermatological monitoring.
Hydroxyurea's potential mutagenicity necessitates a re-evaluation of risk factors in skin cancer development.
Consideration of HU's role in skin carcinogenesis is crucial, especially in sun-exposed individuals.