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Steatosis in chronic hepatitis B: prevalence and correlation with biochemical, histologic, viral, and metabolic

Archana Rastogi1, Puja Sakhuja, Ashish Kumar

  • 1Department of Pathology, GB Pant Hospital, New Delhi, India.

Indian Journal of Pathology & Microbiology
|September 22, 2011
PubMed

Insights

Hepatic steatosis (fatty liver) affects one-third of patients with chronic hepatitis B. High triglyceride levels are linked to fatty liver, while HBV DNA levels show a negative correlation.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Viral Hepatitis Research

Background:

  • Hepatic steatosis (HS) is common in chronic hepatitis C, impacting disease progression and treatment response.
  • Limited data exists on HS prevalence and predictors in chronic hepatitis B (CHB) patients.
  • Understanding HS in CHB is crucial due to the limited efficacy of current antiviral therapies.

Purpose of the Study:

  • To investigate the prevalence and identify predictors of hepatic steatosis in patients with chronic hepatitis B.
  • To compare anthropometric, histological, biochemical, virological, and metabolic factors between CHB patients with and without steatosis.

Main Methods:

  • Analysis of liver biopsies from 350 consecutive patients with chronic Hepatitis B Virus (HBV) infection.
  • Categorization into Group I (steatosis >5%) and Group II (no steatosis ≤5%).
  • Logistic regression analysis to determine independent predictors of steatosis.

Main Results:

  • 118 patients (33.7%) had hepatic steatosis, with 55.1% having mild and 44.9% moderate to severe steatosis.
  • Patients with steatosis were older, predominantly male, more frequently obese, and had higher triglyceride, cholesterol, and serum insulin levels.
  • Lower HBV DNA levels were observed in patients with steatosis; HBV genotype did not influence HS prevalence.

Conclusions:

  • Hepatic steatosis is present in approximately one-third of patients with HBV-related chronic liver disease.
  • Host metabolic factors, particularly elevated serum triglyceride levels, are significantly associated with HS in CHB.
  • HBV DNA levels demonstrated a negative correlation with the presence of hepatic steatosis.
Abstract

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