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Transfusion-induced hemoglobinopathy in patients of beta-thalassemia major

Sanjeev K Gupta1, Monica Sharma, Seema Tyagi

  • 1Department of Haematology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. drskgupta1@gmail.com

Indian Journal of Pathology & Microbiology
|September 22, 2011
PubMed

Apparent hemoglobinopathy acquired after blood transfusion is an uncommon cause of diagnostic dilemma resulting in repeated testing and delay in the diagnosis. Out of the 1530 hemoglobin (Hb)-high-performance liquid chromatography (HPLC) performed at our hospital (May 2009 to April 2010), 3 pediatric cases of thalassemia major were detected having posttransfusion hemoglobinopathy with HbS ranging from 9.9% to 18.5%. In all three cases, there was no variant hemoglobin in earlier documented Hb-HPLC. It is important to be aware of and consider apparent transfusion-induced hemoglobinopathy in patients with unusual percentage of variant hemoglobin to avoid unnecessary treatment and counseling.

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