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Related Experiment Video

Updated: May 29, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

A case hypersensitive to bimatoprost and dexamethasone.

Xiaohong Li¹, Guo Liu, Yun Wang

¹Department of Ophthalmology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. xliu1213@yahoo.com.cn

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics

|September 23, 2011

Summary

This case study highlights a patient hypersensitive to topical bimatoprost and dexamethasone, showing unique ocular responses. Genetic analysis revealed variations potentially explaining treatment resistance and hypersensitivity in glaucoma management.

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Area of Science:

Ophthalmology
Genetics
Pharmacology

Background:

A 41-year-old female with secondary glaucoma experienced treatment failure with multiple topical medications.
The patient showed responsiveness to bimatoprost but hypersensitivity to dexamethasone, which paradoxically increased intraocular pressure (IOP).

Observation:

Ultrasound biomicroscopy revealed cyclodialysis after bimatoprost use, which resolved with dexamethasone-induced ocular hypertension.
A complex interplay was observed where bimatoprost lowered IOP, and dexamethasone raised it, with each drug counteracting the other's effect.

Findings:

Genetic analysis identified variations in the prostaglandin F receptor (FP) gene (rs3753380, rs3766355) and myocilin gene (-224T>C).
A novel heterozygous Cys346Tyr mutation was found in the prostaglandin E receptor 2 (EP2) gene, with no variations in the EP1 gene.

Implications:

Bimatoprost-induced cyclodialysis may explain hypersensitivity, potentially linked to receptor selectivity.
Genetic variations in FP and EP2 genes might contribute to the patient's unresponsiveness to other prostaglandin analogs and unique drug responses.
Myocilin gene variation could influence dexamethasone's effect on gene expression and IOP regulation.