[Polyneuropathy associated with osteosclerotic myeloma. Excellent response to chemotherapy]

We report a 36-year-old patient with progressive tetraparesis and diffuse osteosclerotic lesions without secretion of a monoclonal component, in whom a diagnosis of non-secreting diffuse osteosclerotic myeloma with POEMS syndrome was made with open rib biopsy. We discuss the clinical, biological, radiological and electrophysiological features of this patient. We analyze the possible pathogenesis of his neurological involvement, with a detailed review of the relevant literature. Finally, we underline the therapeutic success with a combination of cyclophosphamide and prednisone, comparing it with the previous references to this therapeutic modality, and emphasize the validity of our therapeutic approach.