Related Experiment Video
Updated: May 29, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
[Danger signals and inflammasomes in autoinflammatory and autoimmune diseases]
1Institut for Inflammationsforskning, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark. klausben@me.com
Abstract:
Cytoplasmic inflammasomes are formed through activation of pattern recognition receptors (PRR) of the innate immune system. Endogenous and exogenous danger signals, e.g. DNA- and RNA-fragments, urate- and cholesterol crystals, silica and asbestos, ß-amyloid, UV-light and skin irritants, may induce NOD-like receptor protein (NLRP)3 inflammasomes. These inflammasomes govern the induction of proinflammatory cytokines such as IL-1ß, IL-18 and IL-33. PRR and inflammasome dysfunctions may underly immunoinflammatory diseases such as gout and other arthritides, type 1 diabetes and arteriosclerosis.
More Related Videos
Related Concept Videos
Inflammatory Bowel Disease III: Crohn's Disease
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Inflammation: Introduction
Inflammation
Acute Inflammation I: Inflammatory Response
Chronic Inflammation: Introduction

