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Updated: May 29, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Coronary artery bypass surgery provides long-term results superior to percutaneous coronary intervention
Franklin L Rosenfeldt1, Mark D Wilson, Brian F Buxton
1Department of Surgery, The University of Melbourne, Australia. f.rosenfeldt@alfred.org.au
Insights
Coronary artery bypass surgery (CABG) offers better long-term outcomes than percutaneous coronary intervention (PCI) for most patients with significant coronary artery disease (CAD). PCI should be reserved for specific cases where its benefits are proven.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Historically, medical management was primary for coronary artery disease (CAD), with surgery as a secondary option.
- Percutaneous coronary intervention (PCI) has gained popularity as a minimally invasive primary treatment for CAD.
- Emerging evidence questions the long-term superiority of PCI over traditional surgical approaches.
Purpose of the Study:
- To analyze recent evidence comparing long-term outcomes of PCI and coronary artery bypass surgery (CABG).
- To identify patient subgroups who benefit more from surgical revascularization versus PCI.
- To provide recommendations for optimal treatment allocation in CAD management.
Main Methods:
- Review and analysis of recent clinical trials and registries.
- Comparative assessment of long-term prognostic benefits between PCI and CABG.
- Identification of patient characteristics influencing treatment outcomes.
Main Results:
- Coronary artery bypass surgery (CABG) demonstrates superior long-term prognostic benefits compared to percutaneous coronary intervention (PCI) in many patients with significant coronary artery disease (CAD).
- Patients with complex atherosclerotic lesions, multivessel disease, left main stem disease, left ventricular dysfunction, and diabetes mellitus experience greater benefits from CABG.
- PCI's role should be limited to patient groups where its superiority or equivalence to CABG is established.
Conclusions:
- Surgical revascularization (CABG) remains the preferred treatment for complex coronary artery disease (CAD) and specific patient profiles.
- Percutaneous coronary intervention (PCI) should be reserved for selected cases with proven efficacy compared to CABG.
- Multidisciplinary team decision-making is crucial for ensuring optimal, long-term effective therapy for all CAD patients.
Abstract:
Traditionally, patients presenting with symptoms of coronary artery disease (CAD) were managed medically. If medical treatment proved unsuccessful, patients were referred for coronary artery bypass surgery (CABG). However, in recent years, increasing numbers of patients have received percutaneous coronary intervention (PCI), usually a coronary stent, for primary treatment. PCI is attractive because it is minimally invasive, has proven success in the immediate treatment of acute myocardial infarction and is well-accepted for poor surgical candidates in selected cases. However, evidence from emerging and ongoing clinical trials and registries suggests that compared to PCI, CABG offers superior long-term prognostic benefits in many, if not most, patients with significant CAD. We present an analysis of recent evidence showing that patients with complex atherosclerotic lesions, multivessel disease, left main stem disease, left ventricular dysfunction and diabetes mellitus derive more benefit from surgical revascularisation than from PCI. We conclude that PCI should be restricted to patient groups where superiority or equivalence to CABG has been demonstrated and that the decision-making process in allocating treatment should be made by a multidisciplinary team to ensure that every patient receives balanced advice and therapy that is most effective in the long term.
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