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Regulation of Angiogenesis and Blood Supply

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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Updated: May 29, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

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Capillary vessels in Ewing's sarcoma: Overlooked?

Purnima Malhotra¹, Harsh Hora, Usha Agrawal

¹Institute of Pathology, Safdarjang Hospital Campus, Post Box 4909, New Delhi - 110 029, Delhi, India.

Journal of Cytology

|September 23, 2011

Summary

No abstract available in PubMed .

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