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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
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Published on: August 14, 2019

Regional brain axial and radial diffusivity changes during development.

Rajesh Kumar1, Haidang D Nguyen, Paul M Macey

  • 1Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California 90095-1763, USA.

Journal of Neuroscience Research
|September 23, 2011
PubMed
Summary
This summary is machine-generated.

Brain development involves significant changes in myelination and axons. This study establishes normative values for axial and radial diffusivity, revealing age and sex differences crucial for diagnosing developmental brain conditions.

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Area of Science:

  • Neuroimaging
  • Developmental Neuroscience
  • Biomedical Engineering

Background:

  • The developing human brain undergoes rapid myelination and axonal changes throughout childhood, adolescence, and early adulthood.
  • Accurate normative values for brain fiber characteristics are essential for pathological assessment.
  • Existing diffusion tensor imaging (DTI) measures, like axial and radial diffusivity, are not widely established for the developing brain.

Purpose of the Study:

  • To establish normative values for axial and radial diffusivity in widespread brain regions of healthy developing individuals.
  • To investigate age-related changes in axial and radial diffusivity.
  • To evaluate gender differences in axial and radial diffusivity.

Main Methods:

  • Diffusion tensor imaging (DTI) data were acquired from 30 healthy subjects (ages 8-24 years) using a 3.0-Tesla MRI scanner.
  • Axial and radial diffusivity maps were calculated and normalized to a common space.
  • Regions of interest were defined in various brain areas, and average diffusivity values were computed.

Main Results:

  • Axial and radial diffusivity values generally declined with age across most brain regions, with an exception in the midhippocampus where axial diffusivity increased with age.
  • Significant gender differences in diffusivity values were observed in multiple brain areas, including the putamen, thalamus, hypothalamus, cerebellum, limbic, temporal, and cortical regions.
  • Age-related declines and sex-based variations in fiber characteristics were documented.

Conclusions:

  • Normative data for axial and radial diffusivity in the developing brain were successfully documented.
  • These findings highlight significant age- and gender-related changes in brain white matter microstructure.
  • The results underscore the necessity of considering age and sex when evaluating developmental brain pathology using DTI measures.