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Related Experiment Videos

Glycine and experimental spinal spasticity.

P V Hall, J E Smith, J Lane

    Neurology
    |February 1, 1979
    PubMed
    Summary

    Spasticity may involve reduced spinal cord inhibition. This study found decreased glycine and serine activity in spastic cats, suggesting reduced glycine turnover and impaired postsynaptic inhibition.

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    Area of Science:

    • Neuroscience
    • Spinal Cord Physiology
    • Neurochemistry

    Background:

    • Spasticity is a neurological condition characterized by increased muscle tone and exaggerated reflexes.
    • Segmental spinal disinhibition is a proposed mechanism contributing to spasticity.
    • Glycine is a key inhibitory neurotransmitter in the spinal cord, and serine is its precursor.

    Purpose of the Study:

    • To investigate the role of glycine and serine metabolism in feline spasticity.
    • To determine the content and specific activity of glycine and serine in the spinal cord of spastic cats.
    • To assess the relationship between glycine/serine levels and spinal postsynaptic inhibition.

    Main Methods:

    • Intra-aortic administration of labeled precursors (14C-D-glucose and 14C-L-serine) in feline models.
    • Measurement of glycine and serine content and specific activity in different regions of the spinal cord gray matter.
    • Comparison of biochemical data between spastic and control animals.

    Main Results:

    • Specific activities of both glycine and serine were significantly reduced in the ventromedial, central, and dorsal spinal gray matter of spastic cats.
    • Glycine content remained unchanged, while serine content increased in the spinal cord of spastic animals.
    • These findings indicate reduced glycine turnover in spasticity.

    Conclusions:

    • The study suggests that decreased glycine turnover, likely due to diminished release, contributes to spasticity.
    • The results support neurophysiological evidence indicating a deficit in spinal postsynaptic inhibition in spastic conditions.
    • Altered glycine and serine metabolism may be a significant factor in the pathophysiology of spasticity.

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