Design and synthesis of a library of chemokine antagonists
Gurdip Bhalay1, Birgit Albrecht, Mohammed Akhlaq
1Global Discovery Chemistry, Novartis Institutes of Biomedical Research, Horsham Research Centre, Wimblehurst Road, Horsham, West Sussex RH12 5AB, UK. gurdip.bhalay@novartis.com
Bioorganic & Medicinal Chemistry Letters
|September 24, 2011
Abstract:
A library of chemokine antagonists has been synthesized using a combination of solid and solution-phase chemistry. Structures of known chemokine antagonists were used to produce a pharmacophore which served to guide monomer selection. Several combinations of monomers have resulted in providing novel chemokine antagonists which in some cases display dual chemokine receptor antagonism.


