Related Experiment Video
Updated: May 29, 2026

08:21
Non-invasive Assessments of Subjective and Objective Recovery Characteristics Following an Exhaustive Jump Protocol
Published on: June 8, 2017
Resistance exercise inter-set cooling strategy: effect on performance and muscle damage.
Pedro Galoza1, Felipe Sampaio-Jorge, Marco Machado
1Laboratory of Human Movement Studies, University Foundation of Itaperuna, Itaperuna, Brazil.
International Journal of Sports Physiology and Performance
|September 24, 2011
Summary
Applying inter-set cooling during resistance exercise (RE) increased repetitions by 21% without elevating muscle damage biomarkers. This strategy enhances workout volume safely.
Area of Science:
- Exercise Physiology
- Sports Science
- Muscle Physiology
Background:
- Resistance exercise (RE) is crucial for muscle strength and hypertrophy.
- Optimizing RE protocols to maximize performance and minimize fatigue is an ongoing area of research.
- Inter-set rest strategies can influence training outcomes.
Purpose of the Study:
- To investigate the impact of inter-set cooling on total repetitions during RE.
- To compare muscle damage biomarker responses between cooling and no-cooling conditions.
- To determine if external cooling affects performance and muscle damage markers.
Main Methods:
- Sixteen healthy men were randomized into Cooling and Control groups.
- Participants performed four sets of biceps curls to fatigue at 80% of one-repetition maximum (1RM).
- The Cooling group received ice application during rest intervals; the Control group did not.
Main Results:
- The Cooling group performed approximately 21% more repetitions than the Control group.
- No significant differences were observed in serum creatine kinase (CK) activity between groups.
- Myoglobin concentration responses also showed no significant differences between the Cooling and Control groups.
Conclusions:
- Inter-set external cooling can enhance the number of repetitions achieved during resistance exercise.
- This cooling strategy does not appear to increase markers of muscle damage.
- External cooling may be a viable method to augment training volume in resistance exercise protocols.
Related Concept Videos
Exercise and Muscle Performance
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Exercise and Cardiovascular Response
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Muscle Recovery and Fatigue
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Exercise Stress Test
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Responses to Heat and Cold Stress
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.

