Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating Perspectives on Empathy in Anesthesiology Trainees: A Mixed-Methods Study of Pre-Anesthesia Encounters.

Anesthesia and analgesia·2026
Same author

Dynamic sensor selection for biomarker discovery.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Geometric Aspects of Observability of Hypergraphs.

IFAC-PapersOnLine·2025
Same author

KRONECKER PRODUCT OF TENSORS AND HYPERGRAPHS: STRUCTURE AND DYNAMICS.

SIAM journal on matrix analysis and applications : a publication of the Society for Industrial and Applied Mathematics·2025
Same author

Automatic biomarker discovery and enrichment with BRAD.

Bioinformatics (Oxford, England)·2025
Same author

A Hands-On Introduction to Data Analytics for Biomedical Research.

Function (Oxford, England)·2025
Same journal

The nucleus as a mechanobiological hub in muscle aging.

Nucleus (Austin, Tex.)·2026
Same journal

Intrinsically disordered regions facilitate Mlp1-Nab2 recognition in mRNA quality control.

Nucleus (Austin, Tex.)·2026
Same journal

High-resolution nuclear cell biology by cryo-electron tomography.

Nucleus (Austin, Tex.)·2026
Same journal

Nuclei on the move: LINC complex-dependent and -independent mechanisms of nuclear migration in development.

Nucleus (Austin, Tex.)·2026
Same journal

Integration of nuclear mechanosensing with integrin-extracellular matrix adhesions.

Nucleus (Austin, Tex.)·2026
Same journal

Antagonistic contributions of A-type and B-type lamins to LBR localization and dynamics.

Nucleus (Austin, Tex.)·2026
See all related articles

Related Experiment Video

Updated: May 29, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Losing control: cancer's catastrophic transition.

Indika Rajapakse1, David Scalzo, Mark Groudine

  • 1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Nucleus (Austin, Tex.)
|September 24, 2011
PubMed
Summary
This summary is machine-generated.

Cancer can emerge rapidly, not just gradually. A single catastrophic genomic event can cause massive rearrangements, leading to sudden cancer development, challenging traditional views of cancer progression.

More Related Videos

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle
12:19

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Published on: June 7, 2024

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion
05:23

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Published on: July 7, 2023

Related Experiment Videos

Last Updated: May 29, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle
12:19

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Published on: June 7, 2024

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion
05:23

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Published on: July 7, 2023

Area of Science:

  • Complex systems biology
  • Genomics
  • Cancer research

Background:

  • Complex systems exhibit adaptability and emergent properties.
  • Cellular structures, like the nucleus, function as complex systems.
  • Disruptions in these systems are implicated in diseases such as cancer.

Purpose of the Study:

  • To investigate the timeline of cancer emergence.
  • To challenge the conventional view of gradual cancer progression.
  • To explore the role of genomic events in rapid cancer development.

Main Methods:

  • Analysis of DNA sequences from diverse cancer samples.
  • Comparative genomic analysis.
  • Identification of massive genomic rearrangement events.

Main Results:

  • Cancer development can be rapid rather than gradual.
  • A single catastrophic event can trigger sudden cancer emergence.
  • Massive genomic rearrangements are associated with rapid cancer development.

Conclusions:

  • Cancer progression can occur suddenly due to catastrophic genomic events.
  • This challenges the established model of slow, stepwise cancer development.
  • Understanding rapid cancer emergence is crucial for disease intervention.