Related Experiment Video
Updated: May 29, 2026
07:00
A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia.
B Klop1, T M van den Berg, A P Rietveld
1Department of Internal Medicine, Center for Diabetes and Vascular Medicine, St. Franciscus Gasthuis, P.O. Box 10900, 3004 BA Rotterdam, The Netherlands.
International Journal of Vascular Medicine
|September 24, 2011
Summary
The angiotensin II type 1 receptor (AT1R) A1166C gene variant, specifically the 1166-C allele, is linked to higher postprandial lipemia, impacting triglyceride metabolism. This finding reinforces the connection between the renin-angiotensin system and lipid processing.
Area of Science:
- Cardiovascular Genetics
- Metabolic Research
- Molecular Biology
Background:
- Emerging evidence implicates the renin-angiotensin system in regulating triglyceride metabolism.
- The angiotensin II type 1 receptor (AT1R) gene is a key component of this system.
- Genetic variations in the AT1R gene may influence lipid profiles.
Purpose of the Study:
- To investigate the association between common polymorphisms in the AT1R gene (A1166C and C573T) and postprandial lipemia.
- To determine if specific AT1R gene variants affect triglyceride metabolism after a meal.
Main Methods:
- Eighty-two subjects participated in the study.
- Daytime capillary triglyceride levels were measured.
- Postprandial lipemia was quantified using the incremental area under the triglyceride curve.
- Genotyping for the AT1R gene C573T and A1166C polymorphisms was performed.
Main Results:
- Homozygous carriers of the 1166-C allele exhibited significantly higher postprandial lipemia (9.39 ± 8.36 mM*h/L) compared to homozygous carriers of the 1166-A allele (2.02 ± 6.20 mM*h/L) (P < 0.05).
- No significant differences in postprandial lipemia were observed across different C573T polymorphisms.
- The A1166C polymorphism appears to be the primary driver of the observed effects.
Conclusions:
- The 1166-C allele of the AT1R gene is associated with increased postprandial lipemia.
- These findings support the role of the renin-angiotensin axis in triglyceride metabolism.
- Targeting the AT1R gene may offer novel therapeutic strategies for managing dyslipidemia.
Related Concept Videos
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
01:29Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
01:31Adrenergic Receptors: ɑ Subtype
Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase C—inositol-1,4,5-trisphosphate...
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase C—inositol-1,4,5-trisphosphate...
01:16Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
01:26Adrenergic Receptors: β Subtype
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors have equal affinities for...
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors have equal affinities for...