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Related Experiment Video

Updated: May 29, 2026

Extracellular Vesicle Tissue Factor Activity Assay

Extracellular Vesicle Tissue Factor Activity Assay

Published on: December 29, 2023

Tissue factor, blood coagulation, and beyond: an overview.

¹Division of Biological and Physical Sciences, Delta State University, Cleveland, MS 38733, USA.

International Journal of Inflammation

|September 24, 2011

Summary

This summary is machine-generated.

Tissue factor (TF) plays a critical role beyond blood coagulation, influencing inflammation, cancer, and cardiovascular disease. Targeting TF offers therapeutic potential for various pathological conditions.

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Last Updated: May 29, 2026

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Published on: February 14, 2017

Area of Science:

Biochemistry
Pathophysiology
Molecular Biology

Background:

Tissue factor (TF) is classically known for initiating extrinsic blood coagulation and its link to cardiovascular risks.
TF overexpression is observed in numerous clinical conditions, suggesting broader roles.
Emerging evidence highlights TF's involvement in inflammation, diabetes, obesity, cancer, and more.

Purpose of the Study:

To review the diverse biological and pathogenic roles of tissue factor (TF).
To discuss TF's involvement in various disease developments and manifestations.
To explore therapeutic strategies targeting TF.

Main Methods:

Review of seminal observations and biochemical mechanisms.
Discussion of coagulation-dependent and noncoagulation-mediated actions of TF.
Analysis of TF signaling through protease-activated receptors (PARs).

Main Results:

TF initiates blood coagulation and contributes to thrombotic events.
TF overexpression fuels a coagulation-inflammation-thrombosis circuit.
TF signaling via PARs elicits cellular activation and inflammatory responses.

Conclusions:

TF has a broad spectrum of biological functions extending beyond coagulation.
TF's pathogenic roles are implicated in diverse diseases, including cardiovascular conditions and cancer.
Therapeutic strategies like TF suppression, anticoagulation, PAR blockade, and anti-inflammation show promise.