Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

12.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
12.5K
Combined Effects of Drugs: Antagonism01:30

Combined Effects of Drugs: Antagonism

11.8K
The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
11.8K
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

82
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
82
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

1.1K
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
1.1K
Inflammation: Introduction01:28

Inflammation: Introduction

84
Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
84
Inflammation01:38

Inflammation

46.8K
Overview
46.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quarter-Century Explorations of Bioactive Polyphenols: Diverse Health Benefits.

Frontiers in bioscience (Landmark edition)·2022
Same author

Tissue factor, blood coagulation, and beyond: an overview.

International journal of inflammation·2011
Same author

Polycations selectively blocking tissue factor-dependent FVII activation: collective in vitro anticoagulation studies.

Inflammation & allergy drug targets·2010
Same author

Blood coagulation as an intrinsic pathway for proinflammation: a mini review.

Inflammation & allergy drug targets·2009
Same author

Role of tissue factor in thrombosis. Coagulation-inflammation-thrombosis circuit.

Frontiers in bioscience : a journal and virtual library·2005
Same author

Tissue factor mediates inflammation.

Archives of biochemistry and biophysics·2005

Related Experiment Video

Updated: May 5, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.0K

Antagonism by bioactive polyphenols against inflammation: a systematic view.

Arthur J Chu1

  • 13540 MacNichol Trail, West Bloomfild, MI 48323, USA. ajchu91@hotmail.com.

Inflammation & Allergy Drug Targets
|November 21, 2013
PubMed
Summary

Polyphenols combat chronic inflammation by targeting multiple pathways and reducing inflammatory mediators. These compounds promote resolution of inflammation, restore tissue homeostasis, and offer broad health benefits for disease prevention.

More Related Videos

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

18.7K

Related Experiment Videos

Last Updated: May 5, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.0K
Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

18.7K

Area of Science:

  • Immunology and Molecular Biology
  • Natural Product Chemistry

Background:

  • Inflammation is a critical innate immune response to infection and injury, involving numerous signaling pathways and transcription factors.
  • Failure to resolve inflammation leads to chronic inflammatory diseases like cardiovascular diseases, diabetes, obesity, and cancers.
  • Key inflammatory pathways include PI3K/AkT/mTORC1, JAK/STAT, and transcription factors such as NFκB and AP-1.

Purpose of the Study:

  • To systematically review the anti-inflammatory mechanisms of polyphenols.
  • To elucidate how polyphenols target multiple inflammatory components and reinforce resolution pathways.
  • To highlight the role of polyphenols in preventing and intervening in inflammatory diseases.

Main Methods:

  • Literature review focusing on the molecular mechanisms of polyphenol action in inflammation.
  • Analysis of how polyphenols modulate intracellular signaling pathways (e.g., PI3K/AkT, JAK/STAT, AMPK).
  • Examination of polyphenol effects on transcription factors (e.g., NFκB, AP-1, STAT) and inflammatory mediators.

Main Results:

  • Polyphenols exhibit antioxidant properties and activate AMPK, inhibiting key inflammatory pathways like PI3K/AkT, IKK/JNK, mTORC1, and JAK/STAT.
  • Polyphenols suppress Toll-like receptors (TLRs) and Angiotensin-Converting Enzyme (ACE).
  • These actions lead to the inactivation of NFκB, AP-1, HIF, and STAT, reducing the generation of pro-inflammatory mediators.

Conclusions:

  • Polyphenols effectively resolve inflammation by targeting multiple inflammatory components and reinforcing anti-inflammatory mechanisms.
  • Polyphenols antagonize pro-inflammatory processes, promoting tissue homeostasis and offering diverse health benefits.
  • The findings support the use of polyphenols for the prevention and intervention of inflammatory diseases.