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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Free radical scavenging activity-guided isolation of a diterpenoid from Plectranthus punuctatus
Wossen Kebede1, Daniel Bisrat, Kaleab Asres
1Aromatic, Medicinal and Bioenergy Research Case Team Laboratory, Institute of Ethiopian Agricultural Research, Addis Ababa, Ethiopia.
Abstract:
Free radical scavenging activity-guided investigation of the acetone extract of Plectranthus punuctatus (L'Her) (Lamiaceae) resulted in the isolation of a novel diterpenoid 3,11,12,14,19-pentahydroxy-5,8,11,13-abietatraen-7-pyran[4,6]-16-dione whose structure was elucidated based on spectral evidence. The isolated compound showed a significant antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and deoxyribose degradation assays with IC50 values of 9.65 microg/mL and 5.25 microg/mL, respectively.
