Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual SYK-HDAC Inhibitor Elicits Striking Efficacy against Acute Myeloid Leukemia: Rational Design, Synthesis, and Biological Evaluation.

Journal of medicinal chemistry·2026
Same author

Flavonoids as Dual Topoisomerase I and II Inhibitors: Mechanistic Insights and Emerging Anticancer Strategies.

Chemistry & biodiversity·2026
Same author

Phytochemicals as Promising Therapeutics in Cancer Prevention and Treatment: Mechanisms and Applications.

Current cancer drug targets·2026
Same author

Corrigendum to: Recent Developments in Oral Drug Delivery of Prokinetic Agents: Nanoparticles and Beyond.

Current drug delivery·2026
Same author

Hybrid nanogel system of quercetin-loaded squalene NLCs with zinc-HA network for dry eye syndrome.

International journal of biological macromolecules·2026
Same author

Recent Advances in Bioactive Flavonoids-based Nanotherapeutics as Promising Neuroprotectants in Epilepsy.

Current aging science·2026

Related Experiment Video

Updated: May 29, 2026

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
08:07

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

Microfold-cell targeted surface engineered polymeric nanoparticles for oral immunization.

Basant Malik1, Amit K Goyal, T S Markandeywar

  • 1Nanomedicine Research Centre, Department of Pharmaceutics, Indo-Soviet Friendship College of Pharmacy, Moga, Punjab, India.

Journal of Drug Targeting
|September 28, 2011
PubMed
Summary
This summary is machine-generated.

Novel M-cell targeted nanoparticles offer enhanced oral antigen delivery, protecting against gastric conditions. These Ulex europaeus agglutinin (UEA-1) lectin-coated particles effectively stimulate both systemic and mucosal immunity.

More Related Videos

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination
11:07

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

Related Experiment Videos

Last Updated: May 29, 2026

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
08:07

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination
11:07

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

Area of Science:

  • Biomaterials Science
  • Immunology
  • Nanotechnology

Background:

  • Oral antigen delivery faces challenges due to harsh gastric conditions.
  • Targeting M-cells in the gut-associated lymphoid tissue (GALT) enhances immune responses.
  • Polymeric nanoparticles offer a protective and targeted delivery system.

Purpose of the Study:

  • To develop M-cell targeted polymeric nanoparticles for oral antigen delivery.
  • To protect antigens from degradation in the gastrointestinal tract.
  • To evaluate the immunogenicity of the developed nanoparticle system.

Main Methods:

  • Chitosan nanoparticles were prepared via ionic gelation and loaded with bovine serum albumin (BSA).
  • Nanoparticles were coated with Ulex europaeus agglutinin (UEA-1) lectin conjugated alginate.
  • Characterization included size, shape, zeta-potential, entrapment efficiency, in vitro release, and immunological response in Balb/c mice.

Main Results:

  • UEA-1 lectin-coated nanoparticles demonstrated efficient systemic and mucosal immune responses against BSA.
  • The developed system outperformed aluminium hydroxide gel-based vaccines, particularly in mucosal antibody induction.
  • Analysis of IgG1 and IgG2a isotypes confirmed a mixed TH1/TH2 immune response.

Conclusions:

  • UEA-alginate-coated nanoparticles represent a promising oral delivery system for antigens.
  • This formulation effectively enhances both systemic and mucosal immunity.
  • The targeted delivery approach overcomes challenges associated with oral vaccine administration.