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Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
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The role of targeted therapy in ovarian cancer

Susana Banerjee1, Stan Kaye

  • 1The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom.

European Journal of Cancer (Oxford, England : 1990)
|September 28, 2011
PubMed

Insights

Ovarian cancer, a leading gynecological cancer cause of death, often recurs. Targeted therapies like angiogenesis and PARP inhibitors show promise in early trials for improving ovarian cancer treatment outcomes.

Area of Science:

  • Gynecologic Oncology
  • Molecular Targeted Therapy
  • Clinical Trial Research

Background:

  • Ovarian cancer is a prevalent gynecological malignancy with high mortality.
  • Initial treatments for ovarian cancer frequently face challenges due to disease recurrence and therapeutic resistance.

Purpose of the Study:

  • To review emerging targeted therapeutic strategies for ovarian cancer.
  • To discuss the clinical investigation of novel agents in Phase I and II trials.

Main Methods:

  • Literature review of ongoing clinical trials in ovarian cancer.
  • Focus on targeted agents, including angiogenesis and PARP inhibitors.

Main Results:

  • Several targeted therapies are under clinical investigation for ovarian cancer.
  • Angiogenesis inhibitors and PARP inhibitors represent promising therapeutic avenues.

Conclusions:

  • Targeted therapies offer potential for improved ovarian cancer treatment outcomes.
  • Challenges remain in translating these promising agents into successful clinical practice.

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