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Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
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Complications after prostate biopsy: data from SEER-Medicare.

Stacy Loeb1, H Ballentine Carter, Sonja I Berndt

  • 1Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA. stacyloeb@gmail.com

The Journal of Urology
|September 28, 2011
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Summary

Prostate biopsies lead to a higher risk of hospitalization, especially for infectious complications, which are increasing. Patient selection is crucial to reduce potential harms from this common procedure.

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Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Published on: October 10, 2019

Area of Science:

  • Urology
  • Public Health
  • Infectious Diseases

Background:

  • Over 1 million prostate biopsies are performed annually in the US on Medicare beneficiaries.
  • The risk of serious complications requiring hospitalization following prostate biopsy is a significant concern.
  • Emerging multidrug-resistant organisms may be contributing to an increased risk of infectious complications.

Purpose of the Study:

  • To determine the risk of serious complications requiring hospitalization after prostate biopsy.
  • To investigate the hypothesis that infectious complication risk is increasing due to multidrug-resistant organisms.

Main Methods:

  • A 5% random sample of Medicare participants in SEER regions (1991-2007) was analyzed.
  • Compared 30-day hospitalization rates and diagnosis codes between 17,472 men undergoing prostate biopsy and 134,977 controls.
  • Used multivariate logistic and Poisson regression to assess risk and predictors of complications.

Main Results:

  • The 30-day hospitalization rate post-prostate biopsy was 6.9%, significantly higher than the 2.7% in controls.
  • Prostate biopsy was associated with a 2.65-fold increased risk of hospitalization (p <0.0001).
  • The risk of infectious complications requiring hospitalization increased significantly in recent years (p(trend) = 0.001), associated with later year, nonwhite race, and higher comorbidity scores.

Conclusions:

  • Hospitalization risk within 30 days of prostate biopsy is substantially elevated compared to a control group.
  • Serious noninfectious complications remain stable, but infectious complications have risen.
  • Careful patient selection is essential to mitigate the risks associated with prostate biopsy.