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Related Concept Videos

Gene Therapy00:59

Gene Therapy

27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Faraday Disk Dynamo01:23

Faraday Disk Dynamo

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A Faraday disk dynamo is a DC generator, producing an emf that is constant in time. It consists of a conducting disk that rotates with a constant angular velocity in the magnetic field, perpendicular to the disk's plane. The rotation of the disk causes a change in magnetic flux, which induces an emf, causing opposite charges to develop on the rim and in the center of the disk. The polarity of the induced emf can be determined by the direction of the magnetic field and the direction of the...
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Electric Field of a Charged Disk01:23

Electric Field of a Charged Disk

3.2K
The simplest case of a surface charge distribution is the uniformly charged disk. Calculating its electric field also helps us calculate the electric field of a large plane of charge.
The system's symmetry is in the cylindrical directions across the plane of the charge. As a result, the electric fields created by various surface charge elements nullify each other in the direction parallel to the surface. Thereby, the resulting electric field is perpendicular to the plane. Since the disk is...
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Group Therapy01:26

Group Therapy

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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Gene Flow02:39

Gene Flow

38.1K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
38.1K
Gene Families01:57

Gene Families

10.0K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
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Related Experiment Video

Updated: Feb 15, 2026

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
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Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

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Gene therapy for intervertebral disk degeneration.

Barrett I Woods1, Nam Vo, Gwendolyn Sowa

  • 1The Ferguson Laboratory for Orthopaedic and Spine Research, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. woodbi@upmc.edu

The Orthopedic Clinics of North America
|September 28, 2011
PubMed
Summary
This summary is machine-generated.

Gene therapy offers a novel approach to treating intervertebral disc degeneration by targeting cellular imbalances. Further research is needed to ensure the safety and efficacy of this promising biologic treatment for clinical application.

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Orthopedics

Background:

  • Intervertebral disc degeneration is a widespread condition causing significant pain and disability.
  • Current treatments manage symptoms but do not address the root causes of disc degeneration.
  • Biologic treatments, including gene therapy, are emerging to restore cellular balance in degenerating discs.

Purpose of the Study:

  • To review the advancements in gene therapy for intervertebral disc degeneration.
  • To highlight the potential of gene therapy in correcting catabolic-anabolic imbalance within disc cells.
  • To identify areas requiring further research for clinical translation of gene therapy.

Main Methods:

  • Review of current literature on gene therapy for intervertebral disc degeneration.
  • Analysis of therapeutic gene identification and delivery system development.
  • Evaluation of the pathophysiology of disc degeneration and safety considerations.

Main Results:

  • Significant progress has been made in identifying therapeutic genes for disc degeneration.
  • Development of effective delivery systems has advanced the application of gene therapy.
  • Gene therapy shows promise in addressing the underlying cellular mechanisms of disc degeneration.

Conclusions:

  • Gene therapy represents a novel and promising biologic treatment for intervertebral disc degeneration.
  • Continued investigation into disease pathophysiology and robust safety mechanisms are crucial for clinical translation.
  • Further research is essential to fully realize the potential of gene therapy in treating disc degeneration.