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Bullous photosensitivity to naproxen: "pseudoporphyria"
S M Suarez1, P R Cohen, V A DeLeo
1Department of Dermatology, Columbia-Presbyterian Medical Center, New York, NY 10032.
Arthritis and Rheumatism
|June 1, 1990
Summary
Pseudoporphyria is a reversible skin condition triggered by sunlight and certain medications. Physicians should consider this disorder when patients on nonsteroidal anti-inflammatory drugs develop blisters.
Area of Science:
- Dermatology
- Toxicology
Background:
- Pseudoporphyria is a photo-induced bullous disease with characteristic clinical, histologic, and immunofluorescent findings.
- Porphyrin studies are normal by definition in pseudoporphyria.
Observation:
- This report details a case of pseudoporphyria induced by naproxen, a common nonsteroidal anti-inflammatory drug (NSAID).
- A review of previously reported cases of pseudoporphyria is included.
Findings:
- The incidence of pseudoporphyria is rising due to the widespread use of NSAIDs.
- Naproxen can induce pseudoporphyria, a condition presenting with blisters and skin fragility upon sun exposure.
Implications:
- Physicians must be aware of drug-induced pseudoporphyria as a potential side effect of NSAIDs.
- Prompt evaluation is crucial for patients on NSAIDs who develop bullae or increased skin fragility.
- Recognizing and discontinuing the offending NSAID can lead to a reversible resolution of symptoms.