The emulsified lipid Fabuless (Olibra) does not decrease food intake but suppresses appetite when consumed with...

Area of Science:

• Nutrition Science
• Human Physiology
• Dietary Interventions

Background:

• The lipid emulsion Fabuless (Olibra) is proposed to reduce energy intake (EI) and prevent weight regain via the ileal brake mechanism.
• Previous studies on Fabuless efficacy are inconsistent, as the emulsion was administered within a dairy yoghurt, limiting understanding of its effects under varied dietary conditions.

Purpose of the Study:

• To investigate the efficacy of Fabuless in suppressing post-ingestive satiety and short-term food intake.
• To determine if the form and dietary context of Fabuless administration influence its effects on satiety and subsequent energy intake.

Main Methods:

• A randomized, cross-over study involving 18 lean men.
• Six treatments were administered as a test breakfast: Fabuless lipid emulsion (LE) or lipid control (LC) with water, yoghurt, or a muffin.
• Postprandial appetite sensations were assessed using visual analogue scales (VAS), and ad libitum energy intake was measured at a subsequent lunch meal.

Main Results:

• Fabuless increased feelings of fullness compared to a lipid control, but only when administered within a semi-liquid fermented yoghurt (P<0.05).
• No significant effects on satiety ratings were observed when Fabuless was co-presented with water or a solid food muffin.
• No treatment significantly decreased overall energy or macronutrient intake at the subsequent meal.

Conclusions:

• The effects of lipid emulsions like Fabuless on satiety and energy intake appear to be small.
• The consumption format significantly influences the postprandial satiety effects of lipid emulsions.
• There is no current evidence that Fabuless alters eating behavior at a subsequent meal, irrespective of its administration form.