Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 29, 2026

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

Self-folding immunoprotective cell encapsulation devices.

Christina L Randall1, Yevgeniy V Kalinin, Mustapha Jamal

  • 1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.

Nanomedicine : Nanotechnology, Biology, and Medicine
|September 28, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toward autonomous robotic-assisted and microrobotic surgery.

Science advances·2026
Same author

Definitions and Diagnostic Criteria of Lumbar Spine Instability: A Systematic Review.

The spine journal : official journal of the North American Spine Society·2026
Same author

Endo-Wheat for ascending aortic intramural hematoma: Endo-Wheat versus endo-Bentall.

JTCVS structural and endovascular·2026
Same author

Ascending stent in acute type A as a bridge to open repair.

JTCVS structural and endovascular·2026
Same author

Healing the Vote: Recruiting Pre-Health and Health Professions Students for Voter Mobilization.

Health promotion practice·2026
Same author

Rare co-occurrence of colon cancer and <i>Gastrodiscoides hominis</i> in a human host: A case report and literature review.

IDCases·2026
Same journal

Surface-charge-engineered magnetic silk fibroin nanocarriers for pH-responsive 5-fluorouracil delivery and in vitro magnetic localization.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

PEGylation-associated hemodynamic effects in a rodent model of acute hypersensitivity reaction: Complement activation-mediated mechanisms.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

The evolving landscape of osteoarthritis management: From conventional pharmacotherapy to gene therapy, stem cell therapy and nanotechnology-based therapeutics.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

Dihydroartemisinin-stachyose conjugate (sDHA) improves the oral bioavailability of dihydroartemisinin and antiemphalitic malaria effects.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

L220-derived peptide-bioconjugated carbon nanotubes protect hamsters against amoebic liver abscess through IL-17A-associated immune response.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

Spatiotemporally controlled depletion of efflux-dominant cells enhances intratumoral delivery of nanomedicines.

Nanomedicine : nanotechnology, biology, and medicine·2026
See all related articles

Cell encapsulation therapy uses nanoporous membranes to shield transplanted cells from immune rejection, eliminating the need for immunosuppression. This novel approach shows promise for bioartificial pancreas development.

Area of Science:

  • Biomaterials Science
  • Immunology
  • Cell Biology

Background:

  • Cell encapsulation therapy (CET) offers a method for cell transplantation without immunosuppression.
  • It involves enclosing cells in a semipermeable nanoporous membrane for immunoisolation.
  • This technique is particularly relevant for pancreatic islet cell transplantation.

Purpose of the Study:

  • To describe the fabrication and characterization of novel containers for immunoprotective cell encapsulation.
  • To evaluate the potential of these containers for cell transplantation therapies.
  • To explore their application in developing a bioartificial pancreas.

Main Methods:

  • Fabrication of lithographically structured and self-folded containers.
  • Tuning of container porosity and size.

More Related Videos

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots
08:30

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
10:51

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

Related Experiment Videos

Last Updated: May 29, 2026

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots
08:30

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
10:51

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

  • In vitro characterization of membrane permeability to nutrients and immune components.

    • Main Results:

    • Lithographic patterning allowed for precise control over container shape, size, and porosity.
    • Self-folding transformed 2D membranes into 3D cubes with pores throughout.
    • Pore sizes of approximately 78 nm successfully inhibited IgG diffusion while allowing insulin permeation.

    Conclusions:

    • The developed containers provide effective immunoisolation for encapsulated cells.
    • Tunable nanoporous membranes are crucial for selective nutrient and therapeutic permeation.
    • This technology holds significant potential for creating a functional bioartificial pancreas.