Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Block-and-replace vs. titration antithyroid drug regimen for Graves' hyperthyroidism: two is not always better than one.

Journal of endocrinological investigation·2020
Same author

NEW INSIGHTS INTO THE HYPOTHALAMIC-PITUITARY-THYROID AXIS.

Acta endocrinologica (Bucharest, Romania : 2005)·2019
Same author

Cardiovascular Risk in Patients with Subclinical Hypothyroidism.

European endocrinology·2018
Same author

The Role of Iodine and Selenium in Autoimmune Thyroiditis.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2015
Same author

Hypothyroidism and depression: salient aspects of pathogenesis and management.

Minerva endocrinologica·2013
Same author

Environmental factors and thyroid autoimmunity.

Annales d'endocrinologie·2011
Same journal

Correction: Early in, early out: reproductive lifespan timing and cardiometabolic risk in women.

Journal of endocrinological investigation·2026
Same journal

Adult mice are more susceptible to high-fat diet-induced visceral adiposity and insulin resistance than juvenile mice.

Journal of endocrinological investigation·2026
Same journal

Lactobacillus gasseri alleviates type 2 diabetes via modulation of gut microbiota-host metabolic networks.

Journal of endocrinological investigation·2026
Same journal

Rare causes of exogenous Cushing's Syndrome: a challenge for endocrinologists.

Journal of endocrinological investigation·2026
Same journal

Phase angle and triglyceride-glucose index as biomarkers of glycemic control, body composition and cardiovascular risk in adolescents with type 1 diabetes: a cross-sectional study.

Journal of endocrinological investigation·2026
Same journal

4-Methylumbelliferone for type 1 diabetes therapy: evidence for β-cell protection via EGFR/PI3K/Akt signaling.

Journal of endocrinological investigation·2026
See all related articles

Related Experiment Video

Updated: May 29, 2026

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
04:14

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

Published on: October 6, 2023

Resveratrol and its impact on aging and thyroid function.

L H Duntas1

  • 1Endocrine Unit, Evgenidion Hospital, University of Athens, Athens, Greece. ledunt@otenet.gr

Journal of Endocrinological Investigation
|September 28, 2011
PubMed
Summary
This summary is machine-generated.

Resveratrol, a natural compound, offers cardioprotection and cancer prevention. It regulates metabolism and aging by modulating SIRT1, and impacts thyroid cancer and function.

Related Experiment Videos

Last Updated: May 29, 2026

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
04:14

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

Published on: October 6, 2023

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Resveratrol is a natural polyphenol with antioxidant, anti-inflammatory, and apoptotic properties.
  • It is known to modulate the mammalian silent information regulator 1 (SIRT1) for regulating metabolism and aging.
  • Resveratrol has demonstrated potential in cardioprotection and cancer prevention.

Purpose of the Study:

  • To investigate the effects of resveratrol on thyroid cancer cell growth.
  • To explore the role of resveratrol in regulating thyroid function and metabolism.
  • To elucidate the molecular pathways involved in resveratrol's action, including MAPK and SIRT1.

Main Methods:

  • Analysis of resveratrol's impact on papillary and follicular thyroid cancer cell growth.
  • Investigation of resveratrol's influence on the mitogen-activated protein kinase (MAPK) pathway.
  • Assessment of resveratrol's effects on p53 phosphorylation and thyroid function markers like iodide trapping and TSH secretion.

Main Results:

  • Resveratrol arrested cell growth in papillary and follicular thyroid cancer.
  • Activation of the MAPK pathway and increased p53 phosphorylation were observed.
  • Resveratrol enhanced iodide trapping and TSH secretion, positively affecting metabolism via SIRT1 and PIP5Kγ pathways.

Conclusions:

  • Resveratrol exhibits anti-cancer properties against thyroid tumors through MAPK and p53 modulation.
  • Resveratrol positively influences thyroid function and metabolism by activating SIRT1 and related pathways.
  • The findings highlight resveratrol's therapeutic potential in cancer prevention and metabolic regulation.