Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

65.7K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
65.7K
Hormones of the Pituitary Gland01:27

Hormones of the Pituitary Gland

9.8K
The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
9.8K
The Pituitary Gland01:17

The Pituitary Gland

10.3K
The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
10.3K
Perpendicular-Axis Theorem01:16

Perpendicular-Axis Theorem

4.5K
The perpendicular-axis theorem states that the moment of inertia of a planar object about an axis perpendicular to its plane is equal to the sum of the moments of inertia about two mutually perpendicular concurrent axes lying in the plane of the body.
Consider a circular disc of mass M and radius R lying along an x-y plane. The origin lies at the center of the disc, and the z-axis is perpendicular to the disc's plane. All three axes coincide at the disc's center. The moment of inertia of this...
4.5K
Parallel-axis Theorem01:06

Parallel-axis Theorem

8.2K
The parallel-axis theorem provides a convenient and quick method of finding the moment of inertia of an object about an axis parallel to the axis passing through its center of mass. Consider a thin rod as an example. There is a striking similarity between the process of finding the moment of inertia of a thin rod about an axis through its middle, where the center of mass lies, and about an axis through its end using the conventional method. In the conventional method, the concept of linear mass...
8.2K
The Thyroid Gland01:23

The Thyroid Gland

6.8K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Block-and-replace vs. titration antithyroid drug regimen for Graves' hyperthyroidism: two is not always better than one.

Journal of endocrinological investigation·2020
Same author

Cardiovascular Risk in Patients with Subclinical Hypothyroidism.

European endocrinology·2018
Same author

The Role of Iodine and Selenium in Autoimmune Thyroiditis.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2015
Same author

Hypothyroidism and depression: salient aspects of pathogenesis and management.

Minerva endocrinologica·2013
Same author

Resveratrol and its impact on aging and thyroid function.

Journal of endocrinological investigation·2011
Same author

Environmental factors and thyroid autoimmunity.

Annales d'endocrinologie·2011
Same journal

ANALYSIS OF SHORT-CHAIN FATTY ACIDS AND ASSOCIATION WITH GLUCAGON-LIKE PEPTIDE-1 IN HEALTHY, OBESE, PREDIABETES AND TYPE 2 DIABETES INDIVIDUALS.

Acta endocrinologica (Bucharest, Romania : 2005)·2026
Same journal

ASSESSMENT OF NON-ENDOCRINOLOGIST PHYSICIANS' AWARENESS OF DIABETES TECHNOLOGIES: A NATIONWIDE SURVEY IN TURKEY.

Acta endocrinologica (Bucharest, Romania : 2005)·2026
Same journal

LIPOHYPERTHROPHY: NEW TECHNOLOGY, OLD PROBLEMS.

Acta endocrinologica (Bucharest, Romania : 2005)·2026
Same journal

EARLY REASSURANCE OR FALSE SAFETY? THE FETAL HOME DOPPLER USE IN ACTIVE MONITORING IN THE FIRST TRIMESTER OF PREGNANCY - FROM THE ENDOCRINE PERSPECTIVE.

Acta endocrinologica (Bucharest, Romania : 2005)·2026
Same journal

LEVOTHYROXINE-SIMETHICONE DRUG INTERACTION AND PRESENCE OF MACRO-TSH IN AN INFANT WITH CONGENITAL HYPOTHYROIDISM.

Acta endocrinologica (Bucharest, Romania : 2005)·2026
Same journal

DIAGNOSIS OF ACROMEGALY IN BILATERAL CARPAL TUNNEL SYNDROME AND FOLLOW-UP WITH ULTRASONOGRAPHY: A CASE REPORT.

Acta endocrinologica (Bucharest, Romania : 2005)·2026
See all related articles

Related Experiment Video

Updated: Jan 24, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K

NEW INSIGHTS INTO THE HYPOTHALAMIC-PITUITARY-THYROID AXIS.

L H Duntas1

  • 1University of Athens, Evgenideion Hospital, Unit of Endocrinology, Diabetes and Metabolism, Thyroid Section, Athens, Greece.

Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
PubMed
Summary
This summary is machine-generated.

Thyrotropin-releasing hormone (TRH) regulates the hypothalamic-pituitary-thyroid axis. Resveratrol demonstrates potential as a coadjuvant therapy for thyroid disorders, particularly those involving anxiety and depression.

Keywords:
Hypothalamic-Pituitary Thyroid axisTRHTSHtanycytes

More Related Videos

Healthy Brain-pituitary Slices for Electrophysiological Investigations of Pituitary Cells in Teleost Fish
07:14

Healthy Brain-pituitary Slices for Electrophysiological Investigations of Pituitary Cells in Teleost Fish

Published on: August 16, 2018

8.2K
A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery
04:42

A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery

Published on: February 17, 2023

1.8K

Related Experiment Videos

Last Updated: Jan 24, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K
Healthy Brain-pituitary Slices for Electrophysiological Investigations of Pituitary Cells in Teleost Fish
07:14

Healthy Brain-pituitary Slices for Electrophysiological Investigations of Pituitary Cells in Teleost Fish

Published on: August 16, 2018

8.2K
A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery
04:42

A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery

Published on: February 17, 2023

1.8K

Area of Science:

  • Neuroendocrinology
  • Molecular Biology
  • Pharmacology

Background:

  • The hypothalamic-pituitary-thyroid (HPT) axis is regulated by thyrotropin-releasing hormone (TRH) produced in the hypothalamus.
  • TRH integrates external and internal signals to modulate thyroid hormone secretion via the pituitary and thyroid gland.
  • Factors like leptin and ghrelin influence HPT axis regulation, affecting its setpoint.

Purpose of the Study:

  • To investigate the role of TRH in HPT axis regulation.
  • To explore the effects of resveratrol on the HPT axis and its potential therapeutic applications.
  • To understand the interplay between TRH, other hormones, and neurological pathways.

Main Methods:

  • Analysis of TRH production and regulation in the hypothalamus.
  • Investigation of leptin and ghrelin influences on the HPT axis.
  • Assessment of resveratrol's impact on TRH and TSH mRNA expression in subclinical hypothyroid rats.
  • Evaluation of resveratrol's effect on the Wnt/β-catenin pathway in the hippocampus.

Main Results:

  • TRH is identified as a central regulator of the HPT axis.
  • Leptin influences TRH regulation both directly and indirectly.
  • Resveratrol decreases TSH and TRH mRNA expression in subclinical hypothyroid rats.
  • Resveratrol modulates the Wnt/β-catenin pathway in the hippocampus.

Conclusions:

  • Resveratrol exhibits anxiolytic and antidepressant activity in subclinical hypothyroid models.
  • Resveratrol regulates the HPT axis and impacts the Wnt/β-catenin pathway.
  • Resveratrol shows promise as a coadjuvant therapy for thyroid disorders, especially those with anxiety and depression.
  • Clinicians must consider medications and comorbidities that can disrupt HPT axis regulation.