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Updated: May 29, 2026

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
Minimally invasive mitral valve surgery expands the surgical options for high-risks patients
Michael R Petracek1, Marzia Leacche, Natalia Solenkova
1Vanderbilt Heart and Vascular Institute, Nashville, TN, USA.
Background:
A simplified minimally invasive mitral valve surgery (MIMVS) approach avoiding cross-clamping and cardioplegic myocardial arrest using a small (5 cm) right antero-lateral incision was developed. We hypothesized that, in high-risk patients and in patients with prior sternotomy, this approach would yield superior results compared to those predicted by the Society of Thoracic Surgeons (STS) algorithm for standard median sternotomy mitral valve surgery.
Methods:
Five hundred and four consecutive patients (249 males/255 females), median age 65 years (range 20-92 years) underwent MIMVS between 1/06 and 8/09. Median preoperative New York Heart Association function class was 3 (range 1-4). Eighty-two (16%) patients had an ejection fraction ≤35%. Forty-seven (9%) had a STS predicted mortality ≥10%. Under cold fibrillatory arrest (median temperature 28°C) without aortic cross-clamp, mitral valve repair (224/504, 44%) or replacement (280/504, 56%) was performed.
Results:
Thirty-day mortality for the entire cohort was 2.2% (11/504). In patients with a STS predicted mortality ≥ 10% (range 10%-67%), the observed 30-day mortality was 4% (2/47), lower than the mean STS predicted mortality of 20%. Morbidity in this high-risk group was equally low: 1 of 47 (2%) patients underwent reexploration for bleeding, 1 of 47 (2%) patients suffered a permanent neurologic deficit, none had wound infection. The median length of stay was 8 days (range 1-68 days).
Conclusions:
This study demonstrates that MIMVS without aortic cross-clamp is reproducible with low mortality and morbidity rates. This approach expands the surgical options for high-risk patients and yields to superior results than the conventional median sternotomy approach.
Insights
Minimally invasive mitral valve surgery (MIMVS) without aortic cross-clamping offers a safe and effective alternative, especially for high-risk patients. This approach demonstrates lower-than-predicted mortality and morbidity compared to traditional methods.
Area of Science:
- Cardiovascular Surgery
- Minimally Invasive Techniques
- Surgical Outcomes
Background:
- A novel simplified minimally invasive mitral valve surgery (MIMVS) was developed, utilizing a small incision and avoiding aortic cross-clamping and cardioplegic arrest.
- The approach was hypothesized to offer superior outcomes in high-risk patients and those with prior sternotomy compared to standard median sternotomy procedures.
Purpose of the Study:
- To evaluate the safety and efficacy of MIMVS without aortic cross-clamp.
- To compare MIMVS outcomes against predicted results from the Society of Thoracic Surgeons (STS) algorithm for standard mitral valve surgery.
Main Methods:
- 504 consecutive patients underwent MIMVS between January 2006 and August 2009.
- Procedures included mitral valve repair (44%) or replacement (56%) under cold fibrillatory arrest without aortic cross-clamp.
- Patient data included demographics, preoperative New York Heart Association class, ejection fraction, and STS predicted mortality.
Main Results:
- Overall 30-day mortality was 2.2% (11/504).
- For high-risk patients (STS predicted mortality ≥10%), observed 30-day mortality was 4% (2/47), significantly lower than the predicted 20%.
- Morbidity in high-risk patients was low, with minimal reexploration, neurologic deficit, or wound infection. Median length of stay was 8 days.
Conclusions:
- MIMVS without aortic cross-clamp is a reproducible technique with low mortality and morbidity.
- This approach provides a valuable surgical option for high-risk patients.
- MIMVS demonstrates superior results compared to conventional median sternotomy for mitral valve surgery.
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