Comparison of optic disc topography in the cases with graves disease and healthy controls

To compare the optic nerve head topographic parameters of the cases with Graves disease (GD), and the age and sex-matched control group, by using Heidelberg retinal tomography III.

We evaluated both eyes of 65 patients with GD and 54 age and sex-matched controls. For statistical analysis, Mann-Whitney U test and independent sample t test were used. Statistical significance was set as P < 0.05.

The study group consisted of 22 male (33.8%) and 43 female (66.2%) GD cases with a mean age of 40.3 ± 11.9 years and the control group consisted of 26 male (48.1%) and 28 female (51.9%) healthy controls with a mean age of 36.9 ± 7.6 years. The differences between the age and sexes of the groups were not statistically significant (P = 0.07 and P = 0.11, respectively). The mean intraocular pressure of the study group was 14.6 ± 2.9 mm Hg (range, 8 to 20 mm Hg), whereas in the control group, it was 13.4 ± 2.1 mm Hg (range, 10 to 19 mm Hg). The difference between the intraocular pressures was statistically significant (P = 0.01). The mean retinal nerve fiber layer (RNFL) thickness (0.31 ± 0.08 mm) and the mean RNFL cross-sectional area (1.5 ± 0.43 mm) of the control group were greater than the mean RNFL thickness (0.25 ± 0.06 mm) and the mean RNFL cross-sectional area (1.30 ± 0.32 mm) of the study group (P = 0.02, P = 0.03 respectively).

This result suggests that patients with GD may have thinner RNFL than healthy controls.