Association Between Diet Quality Enhancement and Lower Metabolic Endotoxemia in Women with Different Body Mass Index:
Background:
Chronic low-grade inflammation can cause obesity, with diet playing an important role in promoting or reducing inflammation.
Primary Study Objective:
Examining the relationship between diet quality and the soluble cluster of differentiation 14 (sCD14), lipopolysaccharide (LPS), lipopolysaccharide binding protein (LBP), and toll-like receptor-4 (TLR4) levels in obese individuals compared to healthy people.
Methods/Design:
Body weight, height, waist, hip, and neck circumference were measured, and body mass index (BMI), waist/hip, and waist/height ratio were calculated. Tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), high sensitive C-reactive protein (hs-CRP), LPS, LBP, sCD14, and TLR4 were analysed. Diet Quality Index-International was calculated using the 3-day food consumption record.
Setting:
Conducted in Ankara Numune Training and Research Hospital Endocrine Outpatient Clinic in Turkey.
Participants:
40 women of ages 20-45 with no systemic disease and a BMI between 30.0-39.9 kg/m2 were enrolled in the case group; while 40 healthy women with BMI and age distribution similar to the case group were enrolled in the control group.
Intervention:
Anthropometric measurements, blood samples, and food consumption records were collected.
Results:
While there was no statistically significant difference between the case and control groups in serum sCD14, LPS, LBP, and TLR4 levels (P > .05), the difference in IL-6, TNF-α, and hsCRP levels was found to be statistically significant (P < .05). The mean Diet Quality Index-International total score was 49.88 ± 6.29 in the case group and 54.77 ± 7.41 in the control group (P < .05). A low-level, negative, but significant relationship was detected between the serum sCD14, LBP, and TLR4 means of the case and control groups and Diet Quality Index-International total score. It was determined that a high Diet Quality Index-International total score was correlated with decreased IL-6, TNF-α, hsCRP, sCD14, and TLR4.
Conclusion:
Increased nutritional quality in women with different BMI was associated with lower metabolic endotoxemia.
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