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Related Experiment Video

Updated: May 29, 2026

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
11:13

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Published on: March 13, 2016

Nanofluidic devices for rapid continuous-flow bioseparation.

Pan Mao1, Jianping Fu

  • 1Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|September 28, 2011
PubMed
Summary
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Nanofluidic filter arrays offer faster, higher-resolution biomolecule separation than traditional gel electrophoresis. This study details fabricating a device for rapid, continuous-flow protein separation.

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Biochemistry

Background:

  • Conventional gel electrophoresis is a standard bioseparation technique in laboratories.
  • Gel electrophoresis faces limitations in speed, resolution, throughput, and sample recovery.

Purpose of the Study:

  • To detail the fabrication of a novel two-dimensional nanofluidic filter array device.
  • To demonstrate the device's application in rapid, continuous-flow separation of biomolecules.

Main Methods:

  • Fabrication of a two-dimensional nanofluidic filter array.
  • Implementation of the device for continuous-flow separation of proteins.

Main Results:

  • Engineered nanofluidic sieving structures enable enhanced bioseparation.

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Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow
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Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

Published on: February 4, 2011

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration
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Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration

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Related Experiment Videos

Last Updated: May 29, 2026

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
11:13

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Published on: March 13, 2016

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow
09:45

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

Published on: February 4, 2011

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration
08:43

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration

Published on: February 1, 2022

  • The developed device facilitates rapid separation of proteins.

    • Conclusions:

    • Nanofluidic devices present a superior alternative to gel-based bioseparation.
    • The fabricated filter array shows potential for high-performance biomolecule separation.