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Optimism in relation to inflammation and endothelial dysfunction in older men: the VA Normative Aging Study
Ai Ikeda1, Joel Schwartz, Junenette L Peters
1Department of Society, Human Development, and Health, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Psychosomatic Medicine
|September 28, 2011
Summary
Optimism is linked to lower inflammation and better endothelial function in older men. This study explored the connection between optimism and cardiovascular health markers over time.
Area of Science:
- Psychoneuroimmunology
- Cardiovascular Health
- Aging Research
Background:
- Optimism may reduce cardiovascular disease risk, but underlying mechanisms require elucidation.
- This study investigates the relationship between optimism and changes in inflammation and endothelial function in men.
Purpose of the Study:
- To examine the association between optimism and inflammation.
- To assess the link between optimism and endothelial function over time.
- To explore the role of optimism in cardiovascular health mechanisms in aging men.
Main Methods:
- Longitudinal data from the Normative Aging Study (n=340) were analyzed.
- Optimism was measured using the Life Orientation Test.
- Inflammation and endothelial dysfunction markers (e.g., IL-6, ICAM-1) were assessed repeatedly using serum analysis.
Main Results:
- Higher optimism scores correlated with lower levels of interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1).
- No significant association was found between optimism and the rate of change in these inflammatory markers.
- Pessimism demonstrated stronger associations with outcomes than optimism.
Conclusions:
- Elevated optimism is associated with reduced inflammation and endothelial dysfunction in older men without pre-existing heart disease.
- These findings suggest a potential pathway linking psychological factors to cardiovascular health.
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