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Published on: September 1, 2016

Intravenous clevidipine for management of hypertension

Alma Rivera1, Elsa Montoya, Joseph Varon

  • 1Universidad Autónoma de Chihuahua, Chihuahua, México;

Integrated Blood Pressure Control
|September 28, 2011
PubMed

Insights

Clevidipine, a fast-acting calcium channel blocker, offers a new option for managing acute hypertension, especially in patients with liver or kidney issues. Its rapid action and safe profile make it valuable for urgent blood pressure control.

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Hypertension is a leading global cause of mortality.
  • Current treatments often fail, necessitating new antihypertensive agents.
  • Limited options exist for rapid blood pressure reduction in hypertensive crises.

Purpose of the Study:

  • To review the characteristics of clevidipine.
  • To evaluate clevidipine's role in acute hypertension management.

Main Methods:

  • Literature review of clevidipine's pharmacological properties.
  • Analysis of clinical data regarding its efficacy and safety.

Main Results:

  • Clevidipine is a vasculoselective dihydropyridine calcium channel blocker.
  • It exhibits a rapid onset and offset of action.
  • Metabolism is independent of liver and kidney function, allowing use in patients with dysfunction.

Conclusions:

  • Clevidipine is effective for rapid blood pressure reduction when oral therapy is unsuitable.
  • Its use is beneficial in the perioperative setting.
  • Clevidipine presents a valuable option for managing acute hypertension.

Keywords:
acuteclevidipinehypertension managementhypertensive crisesintravenous

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