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Updated: May 29, 2026
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Multi-locus Variable-number Tandem-repeat Analysis of the Fish-pathogenic Bacterium Yersinia ruckeri by Multiplex PCR and Capillary Electrophoresis
Published on: June 17, 2019
Population structure of the Yersinia pseudotuberculosis complex according to multilocus sequence typing
Riikka Laukkanen-Ninios1, Xavier Didelot, Keith A Jolley
1Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, P.O. Box 66, FI-00014, University of Helsinki, Finland.
Environmental Microbiology
|September 29, 2011
Summary
Multilocus sequence analysis identified Yersinia pseudotuberculosis as a complex of four populations, including Yersinia pestis and Yersinia similis. A novel Korean group may be speciating, with genetic exchange observed between populations.
Area of Science:
- Microbiology
- Genomics
- Bacteriology
Background:
- Yersinia pseudotuberculosis is a significant human pathogen.
- Understanding its genetic diversity is crucial for public health and disease control.
Purpose of the Study:
- To investigate the population structure and genetic diversity of Yersinia pseudotuberculosis.
- To identify distinct genetic groups within the Y. pseudotuberculosis complex.
- To explore the evolutionary relationships and potential for speciation.
Main Methods:
- Multilocus sequence analysis (MLSA) was performed on 417 strains.
- Phylogenetic analysis was used to delineate population structures.
- Virulence factors and genetic markers were assessed.
Main Results:
- MLSA revealed four distinct populations within the Y. pseudotuberculosis complex.
- Three populations were identified as Yersinia pseudotuberculosis sensu stricto, Yersinia pestis, and Yersinia similis.
- A fourth population, the Korean group, shows signs of active speciation.
- Recombination was evident within Y. pseudotuberculosis sensu stricto and between Y. similis and the Korean group.
- Yersinia similis lacks key virulence factors, suggesting it is non-pathogenic.
- Y. pseudotuberculosis sensu stricto, the Korean group, and Y. pestis are pathogenic to humans.
Conclusions:
- Yersinia pseudotuberculosis represents a complex of evolving populations.
- Genetic exchange and mutation drive diversification.
- The Korean group represents a potential new species in the process of formation.
- Pathogenicity varies among the identified Yersinia populations.
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