Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
COP Coated Vesicles00:59

COP Coated Vesicles

Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of different...
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with cytoskeletal...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Four-colour response to self-sorting of mixed monolayer-protected metal nanoparticles.

Chemical communications (Cambridge, England)·2025
Same author

Light and protonation-controlled complex formation between sulfate ions and a stiff-stilbene based bis(cyclopeptide).

Chemical science·2025
Same author

Sulfonatocalix[4]arene-Based Scavengers for V-Type Nerve Agents with Enhanced Detoxification Activity.

Chemistry (Weinheim an der Bergstrasse, Germany)·2024
Same author

Günter Wulff (1935 -2023): Father of Molecular Imprinting.

Angewandte Chemie (International ed. in English)·2024
Same author

Synthetic Receptors Based on Abiotic Cyclo(pseudo)peptides.

Molecules (Basel, Switzerland)·2022
Same author

When Molecules Meet in Water-Recent Contributions of Supramolecular Chemistry to the Understanding of Molecular Recognition Processes in Water.

ChemistryOpen·2022

Related Experiment Video

Updated: May 29, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
09:44

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

Published on: October 15, 2019

Molecular cages and capsules with functionalized inner surfaces.

Stefan Kubik1

  • 1Fachbereich Chemie - Organische Chemie, Technische Universität Kaiserslautern, Germany. kubik@chemie.uni-kl.de

Topics in Current Chemistry
|September 29, 2011
PubMed
Summary

Molecular cages with internal binding sites enhance guest molecule stability. Functionalizing cavities improves host-guest interactions, leading to better affinity and selectivity in supramolecular chemistry.

More Related Videos

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance
08:12

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Published on: September 5, 2018

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
10:07

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

Related Experiment Videos

Last Updated: May 29, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
09:44

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

Published on: October 15, 2019

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance
08:12

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Published on: September 5, 2018

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
10:07

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

Area of Science:

  • Supramolecular Chemistry
  • Organic Chemistry
  • Chemical Engineering

Background:

  • Molecular containers offer kinetic stability but often lack thermodynamic stability due to weak host-guest interactions.
  • Binding in conventional molecular containers is primarily driven by entropic factors, limiting practical applications.
  • Improving thermodynamic stability requires incorporating specific binding sites within the container's cavity.

Purpose of the Study:

  • To review molecular cage receptors functionalized with inwardly directed binding sites.
  • To explore how these binding sites influence host-guest interactions, affinity, and selectivity.
  • To highlight the advantages of molecular cages over traditional molecular containers for enhanced binding.

Main Methods:

  • Classification of molecular cage receptors based on the type of guest-binding interactions.
  • Analysis of receptor architectures designed to incorporate converging binding sites.
  • Review of studies demonstrating the impact of functionalized cavities on binding properties.

Main Results:

  • Functionalizing the inner cavity of molecular cages with binding groups significantly enhances thermodynamic stability.
  • Directed interactions between host and guest improve receptor affinity and selectivity.
  • Molecular cages offer a viable strategy to overcome limitations of conventional molecular containers.

Conclusions:

  • Molecular cages with tailored internal binding sites represent a powerful platform for designing stable and selective host-guest complexes.
  • The strategic placement of binding groups is crucial for optimizing supramolecular interactions.
  • This approach advances the field of molecular recognition and encapsulation.