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Related Concept Videos

Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the appropriate...
Pharmacokinetic–Pharmacodynamic Relationship: Problems01:24

Pharmacokinetic–Pharmacodynamic Relationship: Problems

The empirical approach to drug therapy optimization relies on correlating pharmacological response with administered dosage. Such an approach can be costly, time-consuming, and often yields poor correlation due to variables like formulation factors and drug elimination characteristics. A more precise approach correlates response with plasma drug concentration or the amount of drug in the body, rather than dosage. This is achieved through pharmacokinetic-pharmacodynamic (PK/PD) modeling, which...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

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Ole Isacson: Development of New Therapies for Parkinson's Disease
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Published on: April 29, 2007

Clinical pharmacists and basic scientists: do patients and physicians need this collaboration?

Amir H Zargarzadeh, Susan Jacob, Roger S Klotz

    International Journal of Clinical Pharmacy
    |September 29, 2011
    PubMed
    Summary

    Pharmacists are crucial in patient care, especially in collaborative practice settings. Enhanced pharmacy education integrating basic sciences with clinical application improves patient outcomes and safety.

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    Published on: May 21, 2018

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    Published on: May 21, 2018

    Area of Science:

    • Pharmaceutical Sciences
    • Clinical Pharmacy
    • Healthcare Education

    Background:

    • Pharmacists possess essential knowledge in basic pharmaceutical sciences.
    • Inter-professional collaboration is increasingly recognized as vital for patient care.
    • Existing literature supports the benefits of pharmacists in collaborative practice.

    Purpose of the Study:

    • To emphasize the significant role of pharmacists in patient care.
    • To highlight the advantages of inter-professional collaborative practice.
    • To discuss the integration of basic pharmaceutical sciences into clinical practice.

    Main Methods:

    • Commentary based on existing literature review.
    • Analysis of economic, humanistic, efficacy, and safety perspectives.
    • Discussion on pharmacy curriculum development and inter-professional education.

    Main Results:

    • Pharmacists with strong basic science and clinical skills enhance pharmacotherapy.
    • Collaborative practice settings amplify the positive impact of pharmacists.
    • Evidence supports improved patient care through inter-professional collaboration.

    Conclusions:

    • Pharmacy education must balance basic sciences with clinical application.
    • Inter-professional education is key to achieving comprehensive clinical practice.
    • Pharmacists are integral to optimizing patient care through collaboration.