Related Experiment Video
Updated: May 29, 2026
Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
Published on: August 12, 2018
Treatment of dysarthria following subthalamic nucleus deep brain stimulation for Parkinson's disease
Elina Tripoliti1, Laura Strong, Freya Hickey
1Sobell Department, Unit of Functional Neurosurgery, UCL, Institute of Neurology, Queen Square, London, United Kingdom. e.tripoliti@ion.ucl.ac.uk
Background:
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established treatment for patients with Parkinson's disease (PD). Speech impairment is a frequent side effect of the surgery. This study examined the efficacy of an intensive speech treatment, the Lee Silverman Voice Treatment (LSVT) on dysarthria after STN-DBS.
Methods:
The LSVT was administered to 10 patients with STN-DBS (surgical group) and 10 patients without (medical group). Patients were assessed before, immediately after, and 6 months following the speech treatment using sustained phonation, a speech intelligibility scale, and monologue. Vocal loudness, speech intelligibility, and perceptual ratings were the primary outcome measures.
Results:
Vocal loudness and perceptual scores improved significantly across tasks for the medical group only. Speech intelligibility did not significantly change for either group. Results in the surgical group were variable, with some patients deteriorating.
Conclusions:
Treatment of dysarthria following STN-DBS needs further investigation because of the variable response to LSVT.
