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Updated: May 29, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Reduction in maternal complement levels during delivery by cesarean section.

Makoto Kato¹, Hiroaki Itoh, Kotomi Nagahashi

¹Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu Department of Obstetrics and Gynecology, Kakegawa Municipal General Hospital, Kakegawa, Japan.

The Journal of Obstetrics and Gynaecology Research

|September 30, 2011

Summary

Cesarean sections significantly alter maternal complement and contact systems, with complement 3, complement 4, and coagulation factor XII levels decreasing. Vaginal delivery shows different complement and coagulation factor XII responses.

Related Experiment Videos

Last Updated: May 29, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Area of Science:

Immunology
Obstetrics
Hematology

Background:

Elective cesarean sections are common globally.
Limited data exists on maternal physiological responses to different delivery modes.

Purpose of the Study:

To compare maternal complement and contact system changes between cesarean and vaginal deliveries.
Investigate differences in complement 3, complement 4, and coagulation factor XII levels based on delivery mode.

Main Methods:

Maternal blood samples were collected from women undergoing elective cesarean (n=70) or vaginal (n=140) delivery.
Levels of complement 3 (C3), complement 4 (C4), and coagulation factor XII (FXII) were quantified.

Main Results:

Cesarean delivery led to significant decreases in C3, C4, and FXII levels, which persisted for two hours postpartum.
Vaginal delivery showed a transient increase in C3 levels, while C4 levels remained unchanged.
FXII levels decreased two hours after vaginal delivery.

Conclusions:

Maternal complement and contact system responses differ significantly between cesarean and vaginal deliveries.
Cesarean delivery is associated with a distinct pattern of changes in C3, C4, and FXII compared to vaginal birth.