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Updated: May 29, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Cerebral microbleeds and cognitive functioning in the PROSPER study.

A C G M van Es¹, J van der Grond, A J M de Craen

¹Department of Radiology, Section of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, the Netherlands. A.C.G.M.van_Es@LUMC.nl

|September 30, 2011

Summary

This summary is machine-generated.

Infratentorial cerebral microbleeds (MBs) are linked to cognitive decline in older adults. This study found that MBs in the infratentorial region correlate with lower scores in learning and daily living activities.

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Published on: October 17, 2018

Area of Science:

Neurology
Gerontology
Vascular Medicine

Background:

Cerebral microbleeds (MBs) are markers of cerebral small-vessel disease, increasing with age.
The cognitive impact of MBs in the elderly population is not well understood.
The PROSPER study investigated the association between MBs and cognitive function in aging individuals.

Purpose of the Study:

To determine if the presence and location of cerebral microbleeds (MBs) are associated with cognitive performance in the PROSPER study cohort.
To explore the relationship between infratentorial MBs and cognitive decline in elderly individuals.

Main Methods:

Recorded the number and location of MBs in 439 subjects (cortico-subcortical, deep white matter, basal ganglia, infratentorial).
Utilized a linear mixed model to compare cognitive performance between subjects with and without MBs, adjusting for sex, age, white matter hyperintensity volume, and infarction.
Assessed cognitive differences based on the anatomical location of MBs.

Main Results:

Subjects with infratentorial MBs showed significantly lower scores on the Immediate Picture-Word Learning test.
Delayed Picture-Word Learning scores were also significantly lower in individuals with infratentorial MBs.
Performance on Instrumental Activities of Daily Living was negatively associated with the presence of infratentorial MBs.

Conclusions:

Infratentorial cerebral microbleeds are associated with cognitive impairment in elderly individuals with increased vascular risk.
The findings highlight the clinical significance of MB location in understanding cognitive decline in aging populations.