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Site-selective, cleavable linkers: quality control and the characterization of small molecules on microelectrode
Bo Bi1, Richard Y-C Huang, Karl Maurer
1Department of Chemistry, Washington University, St. Louis, Missouri 63130, United States.
Abstract:
A "safety-catch" linker strategy has been used to release a portion of the products of a Diels-Alder reaction conducted on a microelectrode array for characterization of stereochemistry. The attachment and cleavage of organic compounds from the surface of selected electrodes in the array can be accomplished by site-selective generation of base or acid at the electrode. It was found that the surface of the array had a minor influence on the stereochemistry of the Diels-Alder reaction, leading to slightly more of the exo-product relative to a similar solution-phase reaction.
