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Related Experiment Video

Updated: May 29, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
20:33

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

Automated remote transapical wound closure system study.

Peter A Knight1, Jude S Sauer, James W Kaufer

  • 1Department of Surgery, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. peter_knight@urmc.rochester.edu

The Annals of Thoracic Surgery
|October 1, 2011
PubMed
Summary
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This study presents a new automated method for closing transapical wounds, crucial for cardiac surgery access. The technique successfully closed sites in tissue models, offering a promising advancement for minimally invasive cardiac procedures.

Area of Science:

  • Cardiovascular Surgery
  • Minimally Invasive Procedures
  • Biomedical Engineering

Background:

  • Transapical access is vital for cardiac interventions.
  • Current closure methods can be challenging.
  • A reliable, minimally invasive closure technique is needed.

Purpose of the Study:

  • To evaluate a novel automated system for transapical wound closure.
  • To develop a method for safe percutaneous left ventricular access.
  • To create a readily applicable closure technique for cardiac patients.

Main Methods:

  • Developed and tested novel automated techniques for suture placement.
  • Utilized a transmural apical guidewire for tract creation.
  • Secured sutures with mechanical pledgeted knots after cannula removal.

Related Experiment Videos

Last Updated: May 29, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
20:33

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

Main Results:

  • Successfully created automated transapical closures in 47 ex vivo porcine hearts and 10 human cadavers.
  • Achieved hemostasis in an acute beating heart model in pigs.
  • Automated closures tolerated higher intraventricular pressures (327 mm Hg) than hand-sutured closures (303 mm Hg).

Conclusions:

  • All automated apical closures demonstrated effectiveness.
  • The novel technique shows promise for cardiac surgery.
  • Further evaluation is warranted based on these encouraging early results.