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Development of meloxicam formulations utilizing ternary complexation for solubility enhancement.

Pakistan journal of pharmaceutical sciences·2011

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Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

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Aceclofenac delivery by microencapsulation using LBL self-assembly for delayed release.

Kumar Dharmendra¹, Pandey Manisha, Koshy Mamman Kymonil

¹Department of Pharmaceutics, Babu Banarasi Das National Institute of Technology & Management, Lucknow, UP, India.

Pakistan Journal of Pharmaceutical Sciences

|October 1, 2011

Summary

This summary is machine-generated.

Layer-By-Layer self-assembly created Aceclofenac microcapsules for targeted colon drug delivery. Optimized microcapsules achieved high encapsulation efficiency and near-complete drug release in simulated colonic conditions.

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Area of Science:

Pharmaceutical Sciences
Materials Science
Drug Delivery

Background:

Colonic drug delivery is crucial for treating local diseases and protecting sensitive peptide drugs from digestion.
Conventional oral delivery often fails to deliver drugs effectively to the colon due to degradation in the upper gastrointestinal tract.

Purpose of the Study:

To develop Aceclofenac microcapsules using Layer-By-Layer (LBL) self-assembly for enhanced colonic targeting.
To optimize the formulation factors influencing microcapsule properties and drug release using the Taguchi approach.

Main Methods:

Utilized LBL self-assembly with chitosan and pectin on Aceclofenac microcrystals.
Applied Taguchi methodology to optimize chitosan concentration, pectin concentration, centrifugation speed, and incubation time.
Characterized microcapsules for size, zeta potential, encapsulation efficiency, and morphology (SEM).
Evaluated in-vitro release kinetics in simulated colonic conditions (rat fecal matter).

Main Results:

Successfully fabricated single bilayer Aceclofenac microcapsules with sequential charge reversal indicating successful LBL assembly.
Optimized microcapsules (F5) exhibited an average size of 20µm and 63.83% encapsulation efficiency.
Achieved 98.40% cumulative drug release ex-vivo in the presence of colonic fecal matter.
Release kinetics followed first-order release (R²=0.950) in simulated colonic environment.

Conclusions:

LBL self-assembly is an effective technique for developing Aceclofenac microcapsules for targeted colonic delivery.
The optimized microcapsules demonstrate significant potential for delivering drugs to the colon with high efficiency and controlled release.