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Noncardiac chest pain: current treatment
Ron Schey1, Autumn Villarreal, Ronnie Fass
1Dr. Schey is a Research Fellow at The Neuroenteric Clinical Research Group, where Ms. Villarreal is a Research Associate. Dr. Fass is a Professor of Medicine and Director of the GI Motility Laboratory at the University of Arizona.
Gastroenterology & Hepatology
|October 1, 2011
Summary
Noncardiac chest pain (NCCP) affects many adults. Current treatments focus on gastroesophageal reflux disease (GERD) and visceral hypersensitivity, using proton pump inhibitors or pain modulators.
Area of Science:
- Gastroenterology
- Pain Management
Background:
- Noncardiac chest pain (NCCP) is a prevalent condition, impacting up to 25% of US adults.
- Treatment paradigms for NCCP have significantly advanced, now emphasizing gastroesophageal reflux disease (GERD) and visceral hypersensitivity.
Purpose of the Study:
- To review current therapeutic strategies for noncardiac chest pain.
- To highlight the standard of care for GERD-related NCCP and alternative therapies for non-GERD NCCP.
Main Methods:
- Literature review of recent advancements in NCCP treatment.
- Analysis of established and emerging therapeutic modalities.
Main Results:
- Proton pump inhibitors are the standard for GERD-related NCCP.
- Pain modulators (e.g., tricyclics, trazodone, SSRIs) are primary for non-GERD NCCP.
- Botulinum toxin and hypnotherapy show potential in preliminary studies.
Conclusions:
- NCCP management is increasingly tailored to underlying mechanisms like GERD and visceral hypersensitivity.
- Established pharmacotherapies form the core treatment, with novel approaches under investigation.
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