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Updated: May 28, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
Published on: December 27, 2016
Abstract:
The dynamic model of membrane transport, which describes the changing of ion contents in the cell, cell volume and membrane potential, for the first time, is applied to analysis of the apoptotic processes. It is shown that increasing of permeability of K+, and Cl(-)-channels, decreasing of permeability of Na+ together with degradation of Na+/K+ pump, KCC and NC cotransporters lead to decreasing of cell U937 volume and plasma membrane depolarization at apoptosis induced by staurosporine in concentration 1 microM. The experimental data using at calculations was published in paper (Yurinskaya et al., 2010).
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