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Updated: May 5, 2026

Recombinant Retroviral Production and Infection of B Cells
Published on: February 19, 2011
Translocation mapping exposes the risky lifestyle of B cells
Rachel Patton McCord1, Job Dekker
1Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605-0103, USA.
Abstract:
Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form from a single double-stranded break, revealing that specific loci have an intrinsic predisposition for frequent chromosomal rearrangements.
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