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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
Published on: April 11, 2016
Metagenomics and personalized medicine
Herbert W Virgin1, John A Todd
1Department of Pathology and Immunology, Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Washington University School of Medicine, St. Louis, MO 63110, USA. virgin@wustl.edu
Cell
|October 4, 2011
Summary
The human microbiome influences disease susceptibility, particularly inflammatory conditions. Understanding host-gene-microbial interactions is key to developing personalized treatments for complex diseases.
Area of Science:
- Human Microbiome Research
- Genetics and Disease Etiology
- Immunology and Inflammation
Background:
- The human microbiome, comprising diverse microorganisms, significantly impacts health and disease.
- It plays a crucial role in modulating host immunity and susceptibility to inflammatory diseases like type 1 diabetes, ulcerative colitis, and Crohn's disease.
- Host-gene-microbial interactions are central to the development of multifactorial chronic disorders.
Purpose of the Study:
- To elucidate the role of host-gene-microbial interactions in chronic inflammatory diseases.
- To explore how genome-wide association studies (GWAS) identify disease subtypes.
- To advance understanding of complex disease etiologies and inform therapeutic strategies.
Main Methods:
- Review and synthesis of current research on microbiome, host genetics, and inflammatory diseases.
- Analysis of findings from genome-wide association studies (GWAS) in autoimmune and inflammatory conditions.
- Conceptual framework development for understanding genotype-phenotype relationships in disease.
Main Results:
- Host-gene-microbial interactions are identified as critical determinants in multifactorial chronic diseases.
- GWAS are revealing mechanism-based subtypes of autoimmune and inflammatory disorders.
- Emerging concepts link genetic predispositions with microbial influences on disease phenotypes.
Conclusions:
- A comprehensive understanding of host-gene-microbial interactions is essential for deciphering complex disease etiologies.
- This knowledge will facilitate the development of advanced animal models.
- Personalized therapeutic strategies targeting specific disease phenotypes can be developed.
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